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Diverse bacterial pattern recognition receptors sense the core phage proteome

Nature, Published online: 29 July 2026; doi:10.1038/s41586-026-10852-6

Systematic analysis of prokaryotic STAND NTPases — relatives of animal and plant immune receptors — uncovers diverse antiviral sensors that detect most of the core structural and replicative proteins of bacteriophages.

Mitochondrial metabolism and epigenetic crosstalk drive SASP

Nature, Published online: 29 July 2026; doi:10.1038/s41586-026-10791-2

In senescent cells, mitochondria-derived acetyl-CoA promotes histone acetylation and increases chromatin accessibility at inflammatory gene loci. Inhibition of SLC25A1 attenuates these effects, underscoring the therapeutic potential of targeting mitochondrial metabolism and its epigenetic crosstalk to delay age-related functional decline.

Alternating CO<sub>2</sub> and bicycloalkane copolymerization to circular polyesters

Nature, Published online: 29 July 2026; doi:10.1038/s41586-026-10848-2

A simple organic catalyst enables direct alternating copolymerization of CO2 with bicycloalkanes to produce high-performance polyesters that can be selectively depolymerized and recycled in a closed-loop lifecycle.

Avalanche-like intercalation and intraparticle correlations in graphite

Nature, Published online: 29 July 2026; doi:10.1038/s41586-026-10862-4

Operando optical microscopy shows avalanche-like lithium deintercalation (intercalation) processes as the dilute stages of graphite are emptied (filled), showing how local disorder governs phase-transition dynamics and ion transport in lithium-ion battery electrodes.

Perpendicular switching of polarization in layered ferroelectrics

Nature, Published online: 29 July 2026; doi:10.1038/s41586-026-10839-3

Perpendicular switching of the polarization state in the layered ferroelectric Bi4Ti3O12 is demonstrated by means of trilinear coupling, allowing manipulation of the in-plane polarization component with an out-of-plane electric field.

Weight-four parity checks in a spin-shuttling architecture

Nature, Published online: 29 July 2026; doi:10.1038/s41586-026-10766-3

A silicon spin-qubit device comprising a shuttling bus for transporting qubits is used to achieve parity checks up to weight four, highlighting the feasibility and benefits of incorporating shuttling into semiconductor quantum processors.

Enzymatic glycosylation and amidation reshapes polyene bioactivity

Nature, Published online: 29 July 2026; doi:10.1038/s41586-026-10834-8

Pathways to previously undescribed polyenes, including unusual enzymes that introduce more sugars onto polyene scaffolds, are discovered, and their accessibility through clean and efficient fermentation and potential for safe use as antifungal treatments is described.

A digitally controlled silicon quantum processing unit

Nature, Published online: 29 July 2026; doi:10.1038/s41586-026-10754-7

A silicon quantum processing unit executes high-fidelity multiqubit circuits, with all time-varying control signals generated by a digitally programmed cryogenic complementary metal–oxide–semiconductor controller and delivered to the low-noise, exchange-only qubit device through a high-density superconducting ribbon cable.
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