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Modular in vivo antibody–ADC click to reverse drug resistance in tumours

Nature, Published online: 15 July 2026; doi:10.1038/s41586-026-10789-w

In vivo ligation of clinically used therapeutic antibodies via bioorthogonal click chemistry to antibody–drug conjugates leads to enhanced antitumour activity in heterogeneous and treatment-resistant tumours.

Ammonia pressure controls colloidal metal nitride synthesis in molten salts

Nature, Published online: 15 July 2026; doi:10.1038/s41586-026-10801-3

A molten salt, high-pressure synthesis method enables solution-based production of diverse refractory metal nitride nanocrystals, expanding access to technologically important nitride materials for advanced applications.

A Bayesian framework for longitudinal EHR and genetic discovery

Nature, Published online: 15 July 2026; doi:10.1038/s41586-026-10780-5

A Bayesian generative framework that integrates longitudinal electronic health records with genetic data to identify latent disease signatures is presented.

Rising dust pollution across Europe in a changing climate

Nature, Published online: 15 July 2026; doi:10.1038/s41586-026-10743-w

A database of daily dust metals in Europe is established and a machine learning model shows that transported dust intrusion events over the past decade are linked to changes in atmospheric circulation, while an ice core shows that the increase in dust since pre-industrial times is governed by increasing aridity in North Africa..

People use fast and flat simulation to reason about new games

Nature, Published online: 15 July 2026; doi:10.1038/s41586-026-10722-1

Large-scale behavioural studies show that people approach a new game systematically and adaptively rationally. A cognitive model called the ‘Intuitive Gamer’ offers insights into this process and may inform the design of more flexible AI systems.

Cell-type signatures of Alzheimer’s disease shared across population groups

Nature, Published online: 15 July 2026; doi:10.1038/s41586-026-10793-0

Single-nucleus RNA-seq and ATAC-seq analyses on post-mortem brain samples from African American, Latin and white individuals identify cell-type-specific molecular signatures that are associated with cognitive impairment and/or Alzheimer’s disease across diverse population groups.

Ketogenic diet mediates intestinal tumorigenesis through lipids not ketones

Nature, Published online: 15 July 2026; doi:10.1038/s41586-026-10779-y

A combination of different manipulations in mouse models of spontaneous intestinal adenoma formation dissects the roles of systemic and epithelial ketogenesis versus dietary lipids in ketogenic diet-mediated intestinal tumorigenesis, highlighting the need for nuanced consideration of dietary strategies for cancer prevention.

GPC3-specific dnTGFβRII-armoured CAR T cells for hepatocellular carcinoma

Nature, Published online: 15 July 2026; doi:10.1038/s41586-026-10786-z

Chimeric antigen receptor (CAR) T cells for antitumour therapy ‘armoured’ with a dominant-negative TGFβ receptor II show enhanced efficacy and tolerable safety in patients with advanced hepatocellular carcinoma who have developed resistance or not responded to previous treatment.

In vivo feasibility study of humanoid robots in surgery

Nature, Published online: 08 July 2026; doi:10.1038/s41586-026-10796-x

A systematic evaluation shows that contemporary humanoid robots can perform laparoscopic surgical tasks through teleoperation, highlighting both their promise and key technical challenges before clinical deployment.

Non-genotoxic transplantation and in vivo selection through epitope editing

Nature, Published online: 08 July 2026; doi:10.1038/s41586-026-10737-8

Epitope editing of KIT enables antibody-based, non-genotoxic conditioning that selectively enriches therapeutic BCL11A-edited haematopoietic stem/progenitor cells, supports durable engraftment, preserves clonal diversity and enhances induction of fetal haemoglobin, a therapeutic approach for conditions such as sickle cell disease and β-thalassemia.

Reinforcement learning control of quantum error correction

Nature, Published online: 08 July 2026; doi:10.1038/s41586-026-10759-2

By integrating reinforcement learning with quantum error correction, a quantum computer continuously self-calibrates during computation, achieving record logical error rates and enhanced resilience to drift.

Aneuploidy selects for the acquisition of driver genes in breast cancer

Nature, Published online: 08 July 2026; doi:10.1038/s41586-026-10752-9

Screening of chromosome arm-level aneuploidies uncovers that these alterations select for specific basal-like breast cancer driver genes, including PLGRKT, an oncogene whose tumour-promoting activity is associated with highly stress-resistant mitochondria and enhanced detoxification of reactive oxygen species.

LARES-2 satellite measures frame-dragging effect around the Earth

Nature, Published online: 08 July 2026; doi:10.1038/s41586-026-10715-0

Using LARES-2, LAGEOS and GRACE satellites, researchers measured Earth’s frame-dragging with unprecedented precision, strongly confirming general relativity, constraining alternative gravity theories, and improving measurements of Earth’s tides.
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