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Modular in vivo antibody–ADC click to reverse drug resistance in tumours

Nature, Published online: 15 July 2026; doi:10.1038/s41586-026-10789-w

In vivo ligation of clinically used therapeutic antibodies via bioorthogonal click chemistry to antibody–drug conjugates leads to enhanced antitumour activity in heterogeneous and treatment-resistant tumours.

A queen odour mediates reproductive suppression in a eusocial mammal

Nature, Published online: 15 July 2026; doi:10.1038/s41586-026-10772-5

Naked mole-rat (Heterocephalus glaber) queens produce isopropyl myristate, a low-volatility ester that high-ranking animals detect and avoid, which alters prolactin and progesterone in other females to suppress reproduction and preserve eusocial hierarchy.

Highly fragmented European wetlands with uneven restoration needs

Nature, Published online: 15 July 2026; doi:10.1038/s41586-026-10760-9

Satellite imagery and machine learning used for the mapping of six seminatural open wetland types and land-use disturbance in European countries shows that wetlands are highly fragmented and have uneven restoration needs.

Universal gates from braiding and fusing anyons on quantum hardware

Nature, Published online: 15 July 2026; doi:10.1038/s41586-026-10709-y

A 54-qubit realization of non-Abelian S3 topological order demonstrates that combining anyon braiding with fusion enables universal topological quantum computation.

Quantum statistical plasmonic metacrystals

Nature, Published online: 15 July 2026; doi:10.1038/s41586-026-10782-3

A new class of materials, quantum statistical plasmonic metacrystals, is described, which can selectively transmit different types of light based only on their quantum coherence, showing bands of allowed and forbidden photon statistics.

Ammonia pressure controls colloidal metal nitride synthesis in molten salts

Nature, Published online: 15 July 2026; doi:10.1038/s41586-026-10801-3

A molten salt, high-pressure synthesis method enables solution-based production of diverse refractory metal nitride nanocrystals, expanding access to technologically important nitride materials for advanced applications.

Scalable quasi-pure MOF membranes for energy-efficient gas separations

Nature, Published online: 15 July 2026; doi:10.1038/s41586-026-10655-9

Scalable quasi-pure metal–organic framework membranes achieve near-intrinsic separation performance, enabling energy-efficient industrial gas separations with major cost reductions compared with distillation.

A Bayesian framework for longitudinal EHR and genetic discovery

Nature, Published online: 15 July 2026; doi:10.1038/s41586-026-10780-5

A Bayesian generative framework that integrates longitudinal electronic health records with genetic data to identify latent disease signatures is presented.

Programming fracture resistance in metamaterials via elastic instabilities

Nature, Published online: 15 July 2026; doi:10.1038/s41586-026-10804-0

Elastic instabilities in mechanical metamaterials can be harnessed to programme fracture behaviour, transforming instability from a failure mechanism into a design principle that increases fracture energy by up to tenfold.

Regression to the mean can explain saturation of geomagnetic storms

Nature, Published online: 15 July 2026; doi:10.1038/s41586-026-10757-4

The saturation of geomagnetic activity with solar wind strength can be explained by a regression to the mean effect, suggesting that the impact of extreme geomagnetic storms can be twice as large as previously thought

Metabolite glues as a means of purine sensing and chemotherapeutic response

Nature, Published online: 15 July 2026; doi:10.1038/s41586-026-10790-3

Purines can act as endogenous molecular glues in human cells by anchoring a rate-limiting enzyme in purine biosynthesis to its inhibitor, and modifying this mechanism could provide a way to improve the properties of thiopurine chemotherapeutic drugs.

Rising dust pollution across Europe in a changing climate

Nature, Published online: 15 July 2026; doi:10.1038/s41586-026-10743-w

A database of daily dust metals in Europe is established and a machine learning model shows that transported dust intrusion events over the past decade are linked to changes in atmospheric circulation, while an ice core shows that the increase in dust since pre-industrial times is governed by increasing aridity in North Africa..

People use fast and flat simulation to reason about new games

Nature, Published online: 15 July 2026; doi:10.1038/s41586-026-10722-1

Large-scale behavioural studies show that people approach a new game systematically and adaptively rationally. A cognitive model called the ‘Intuitive Gamer’ offers insights into this process and may inform the design of more flexible AI systems.
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