Nature, Published online: 24 June 2026; doi:10.1038/s41586-026-10810-2

Role of methanesulfonic acid in atmospheric particle nucleation and growth

Nature, Published online: 24 June 2026; doi:10.1038/s41586-026-10568-7

Reply to: On the robustness of topological gap detection via transport

Nature, Published online: 24 June 2026; doi:10.1038/s41586-026-10767-2

Addendum: Transmission of MPXV from fire-footed rope squirrels to sooty mangabeys

Nature, Published online: 24 June 2026; doi:10.1038/s41586-026-10685-3

A massively parallel assay systematically charts the sequence-function landscape of the STING signalling protein, and the findings define molecular principles that tune STING activity and show its functional potential across immune contexts.

Nature, Published online: 24 June 2026; doi:10.1038/s41586-026-10593-6

This Review reflects on the joint power of genetic technologies, including untapped CRISPR–Cas techniques to combat hidden hunger and improve crop resilience, and argues in favour of their combined use to overcome these societal challenges.

Nature, Published online: 24 June 2026; doi:10.1038/s41586-026-10697-z

Chronic dietary cholesterol activates Ral GTPases, which promote LDLR internalization and lysosomal degradation through RalBP1–REPS1 and CTSA, thereby reducing cholesterol clearance, whereas CTSA inhibition restores LDLR function and may offer a therapeutic strategy for cardiovascular disease.

Nature, Published online: 24 June 2026; doi:10.1038/s41586-026-10688-0

AI models for medical diagnostics are vulnerable to membership inference attacks.

Nature, Published online: 24 June 2026; doi:10.1038/s41586-026-10683-5

Integrated pharmacological, biochemical, biophysical and structural analyses of small-molecule β-arrestin inhibitors show how they block β-arrestin engagement with activated GPCRs, revealing their mechanism of action and uncovering a previously unrecognized allosteric regulatory site.

Nature, Published online: 24 June 2026; doi:10.1038/s41586-026-10599-0

A Review of the immunological mechanisms of mRNA–lipid-nanoparticle vaccines for infectious diseases discusses how the components of this vaccine platform can be modified to fine-tune immune responses against challenging pathogens.

Nature, Published online: 24 June 2026; doi:10.1038/s41586-026-10662-w

Optical cooling in two-dimensional semiconductor heterostructures is demonstrated through phonon-assisted interfacial charge transfer, enabling cryogen-free thermal management without stringent quantum-efficiency requirements.

Nature, Published online: 24 June 2026; doi:10.1038/s41586-026-10674-6

A deep-learning model trained on electrocardiogram (ECG) waveforms identifies an easily visible biomarker that predicts sudden cardiac death more accurately than the current clinical state of the art.

Nature, Published online: 24 June 2026; doi:10.1038/s41586-026-10698-y

High-resolution spatial transcriptome analysis of a human embryo at Carnegie stage 6 reveals three distinct developmental trajectories from the epiblast towards amnion, primitive streak and axial mesoderm, and detects the initiation of haematopoiesis before gastrulation, originating from hypoblast rather than epiblast.

Nature, Published online: 24 June 2026; doi:10.1038/s41586-026-10681-7

A versatile platform of miniaturized Fourier-optics-based diffractive elements enables multifunctional pixels that fully control and sense the amplitude, phase and polarization of optical wavefronts for advanced photonic applications.

Nature, Published online: 24 June 2026; doi:10.1038/s41586-026-10625-1

Genetic sequencing of multiple late Neanderthals living less than 52,500 years ago provides an overview of genetic diversity and demonstrates that even low-coverage nuclear genome data can increase resolution of within-Neanderthal diversity.

Nature, Published online: 24 June 2026; doi:10.1038/s41586-026-10677-3

Porous polyacrylonitrile membranes—typically used as non-selective support layers—can be used to achieve effective molecular refining of crude oil at steady state, enabling substantial reductions in energy consumption, cooling water, and CO2 emissions compared with distillation processes.

Nature, Published online: 24 June 2026; doi:10.1038/s41586-026-10708-z

A boron-stabilized oxide-strengthened tantalum alloy combines exceptional room-temperature ductility with record ultrahigh-temperature strength, enabling load-bearing applications above 2,000 °C.

Nature, Published online: 24 June 2026; doi:10.1038/s41586-026-10678-2

Alternate RNA decoding, an understudied process, leads to peptide sequence modifications that can have substantial functional effects on protein stability, tissue-specific proteomes and disease.

Nature, Published online: 24 June 2026; doi:10.1038/s41586-026-10647-9

In Streptomyces spp., a conserved biosynthetic gene megacluster produces an arsenal of distinct antimicrobials that converge on bacterial biotin biosynthesis as a naturally evolved combination therapy.

Nature, Published online: 24 June 2026; doi:10.1038/d41586-026-01720-4

A sense of déjà vu.

Nature, Published online: 24 June 2026; doi:10.1038/d41586-026-01804-1

Soil bacteria make cocktails of molecules that synergistically inhibit the growth of microbial pathogens — suggesting a strategy for tackling antibiotic-resistant infections.