Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-10733-y

Proteotoxic stress drives formation of GRP75-dependent protein aggregates that signal through mitochondria–ER contact sites to activate targeted quality-control pathways, enabling selective clearance of damaged proteins and preserving mitochondrial integrity.

Nature, Published online: 01 July 2026; doi:10.1038/s41586-026-10723-0

Hydrogen-bonding networks engineered with isomeric molecules enable stable, saturated blue perovskite LEDs with record external quantum efficiencies up to 22.0%, advancing high-performance full-colour display technologies.