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Received — 9 July 2026 ⏭ Nature

Chromatin landscape and epigenetic heterogeneity of acute myeloid leukaemia

✇Nature
By: Yotaro Ochi · Markus Liew-Littorin · Yasuhito Nannya · Sofia Bengtzen · Benedicte Piauger · Stefan Deneberg · Martin Jädersten · Vladimir Lazarevic · Jörg Cammenga · Anna Robelius · Lovisa Wennström · Emma Ölander · Senji Kasahara · Nobuhiro Hiramoto · Nobuhiro Kanemura · Nobuo Sezaki · Maki Sakurada · Makoto Iwasaki · Junya Kanda · Yasunori Ueda · Satoshi Yoshihara · Tom Erkers · Nona Struyf · Yu Watanabe · Masanori Motomura · Masahiro M. Nakagawa · Ryunosuke Saiki · Hidehito Fukushima · Koji Okazaki · Suguru Morimoto · Akinori Yoda · Rurika Okuda · Shintaro Komatsu · Guoxiang Xie · Albin Österroos · Ayana Kon · Lanying Zhao · Yuichi Shiraishi · Takayuki Ishikawa · Satoru Miyano · Kotoe Katayama · Seiya Imoto · Shuichi Matsuda · Akifumi Takaori-Kondo · Hiroyuki Aburatani · Hiroshi I. Suzuki · Olli Kallioniemi · Gunnar Juliusson · Martin Höglund · Sören Lehmann · Seishi Ogawa
8 July 2026 at 01:00

Nature, Published online: 08 July 2026; doi:10.1038/s41586-026-10703-4

An ATAC-seq-based approach is used to classify acute myeloid leukaemia (AML) into 16 epigenomic subgroups, and provides insight into the role of non-genetic mechanisms in determining pathogenesis, clinical behaviour and drug sensitivity in this disease.
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