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Normal view

Received — 16 July 2026 ⏭ Nature

Modular in vivo antibody–ADC click to reverse drug resistance in tumours

✇Nature
By: Cristina Simó · Alexander C. Vanover · Ricardo D’Oliveira Albanus · Sandeep Surendra Panikar · Shayla Shmuel · Alex Benton · Jader Giraldo-Guzman · José M. Luna · Yifei Xu · Na-Keysha Berry · Nai Keltee · Jingxia Liu · Farrokh Dehdashti · Patrícia M. R. Pereira
15 July 2026 at 01:00

Nature, Published online: 15 July 2026; doi:10.1038/s41586-026-10789-w

In vivo ligation of clinically used therapeutic antibodies via bioorthogonal click chemistry to antibody–drug conjugates leads to enhanced antitumour activity in heterogeneous and treatment-resistant tumours.
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