Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10833-9

CRISPR–Cas systems transcriptionally tune diverse innate defences using CRISPR RNA-like guides to balance antiviral protection with fitness, and hyperactivate these defences when compromised, establishing a layered bacterial ‘immunity guard’ network.

Nature, Published online: 01 July 2026; doi:10.1038/s41586-026-10574-9

A virtual yeast, an artificial intelligence-driven agent for modelling eukaryotic cellular behaviours, is described.

Nature, Published online: 01 July 2026; doi:10.1038/s41586-026-10723-0

Hydrogen-bonding networks engineered with isomeric molecules enable stable, saturated blue perovskite LEDs with record external quantum efficiencies up to 22.0%, advancing high-performance full-colour display technologies.

Nature, Published online: 10 June 2026; doi:10.1038/s41586-026-10613-5

Molecular glue degraders of the RNA-binding protein HuR have therapeutic potential for BRAF-mutant cancers.

Nature, Published online: 10 June 2026; doi:10.1038/s41586-026-10633-1

Linafexor is a rapidly cleared FXR agonist designed to mimic natural bile acid signalling, achieving transient receptor activation with strong efficacy and reduced toxicity in preclinical and early clinical studies.