❌

Normal view

Engineered TYK2 dependence enables myeloid-selective IL-10 receptor agonism

Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11176-1

A tetravalent nanobody-based myeloid-selective IL-10 receptor agonist recapitulates IL-10’s potent suppression of monocytes, macrophages and dendritic cells while avoiding stimulation of T cells.

RNA synthesis and substrate analog inhibition in the CCHFV polymerase

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10913-w

RNA synthesis and substrate analog inhibition in the CCHFV polymerase

Precise DNA base editing using AlphaFold3-based contact modelling

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10794-z

ContactSeek is an AlphaFold3-driven model that can improve the precision of genome-editing tools.

Optical cooling by interfacial charge transfer in 2D heterostructures

Nature, Published online: 24 June 2026; doi:10.1038/s41586-026-10662-w

Optical cooling in two-dimensional semiconductor heterostructures is demonstrated through phonon-assisted interfacial charge transfer, enabling cryogen-free thermal management without stringent quantum-efficiency requirements.

Queen cell architecture shapes honey bee queen development

Nature, Published online: 03 June 2026; doi:10.1038/s41586-026-10534-3

Worker bee construction behaviour actively engineers a physicochemical niche that is crucial for queen development in honey bees.
❌