Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-11207-x

Methanoglobus dolicholipophagus AA-75 is a thermophilic archaeon isolated from a Chinese petroleum reservoir that converts methanol into methane, carbon dioxide and acetate, and uses saturated and unsaturated fatty acids to produce methane.

Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11167-2

RFdiffusion methods are used to de novo design proteins with water-activating zinc-based active sites adjacent to a peptide substrate binding pocket, yielding highly active, programmable proteases with potential applications in therapeutics, biotechnology and bioremediation.

Nature, Published online: 09 June 2026; doi:10.1038/s41586-026-10763-6

Author Correction: De novo design of quasisymmetric two-component protein cages