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Received — 9 August 2026 ⏭ Nature

Membranolytic peptide programs immunogenic cell death for cancer therapy

✇Nature
By: Yueling Yuan · Lifang Liang · Jie Li · Chengrun Li · Fuxiang Wang · Kai Yan · Chanjuan Su · Jingxian Chen · Fan Lan · Zining Wu · Rupei Du · Yaofeng Zhou · Xiongwei Xiang · Jueqiong Xu · Huosheng Zhou · Long Zou · Zhouming Zhang · Yuhao Zhang · Songyin Huang · Yajing Zhang · Penghui Zhou · Tianmeng Sun · Kaiting Yang · Zhibin Zhao · Zhexiong Lian · Shiyan Xiao · Jianjun Cheng · Yan Bao · Menghua Xiong
5 August 2026 at 01:00

Nature, Published online: 05 August 2026; doi:10.1038/s41586-026-10899-5

The synthetic-acid-responsive membranolytic peptide aMPC16-CA50 induces immunogenic membranolytic cell death in tumour cells, robustly potentiating immune checkpoint blockade therapy.
Received — 9 June 2026 ⏭ Nature
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