Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11112-3

Primary cultured haematopoietic stem and progenitor cells are used to analyse the molecular mechanisms of brain myeloid differentiation, and this platform enabled the identification of elongation factor ELP1 as an important regulator of this process.

Nature, Published online: 29 July 2026; doi:10.1038/s41586-026-10866-0

A strategy using polymeric carbon nitride crystals induces out-of-plane carrier migration by means of internal electric fields applied on facet-selective nanofilms placed on polymer photocatalysts, increasing the apparent quantum efficiency for overall water splitting.

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10833-9

CRISPR–Cas systems transcriptionally tune diverse innate defences using CRISPR RNA-like guides to balance antiviral protection with fitness, and hyperactivate these defences when compromised, establishing a layered bacterial ‘immunity guard’ network.

Nature, Published online: 24 June 2026; doi:10.1038/s41586-026-10662-w

Optical cooling in two-dimensional semiconductor heterostructures is demonstrated through phonon-assisted interfacial charge transfer, enabling cryogen-free thermal management without stringent quantum-efficiency requirements.