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Normal view

Targeted stimulation of motor cortex ensembles drives learned movements

Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11174-3

Optogenetic stimulation of motor-cortex neuron ensembles shows that precisely timed activity in the primary motor cortex can generate learned neural patterns and movements, demonstrating an active role in skilled motor control.

RNA synthesis and substrate analog inhibition in the CCHFV polymerase

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10913-w

RNA synthesis and substrate analog inhibition in the CCHFV polymerase

Structures and inhibition of the Crimean–Congo haemorrhagic fever virus polymerase

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10701-6

Structural studies of Crimean–Congo haemorrhagic fever virus (CCHFV) polymerase reveal the structural basis of CCHFV RNA synthesis and highlight druggable sites for designing both nucleoside antivirals and non-nucleoside antivirals.

CRISPR–Cas regulates expression of embedded anti-phage defence systems

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10833-9

CRISPR–Cas systems transcriptionally tune diverse innate defences using CRISPR RNA-like guides to balance antiviral protection with fitness, and hyperactivate these defences when compromised, establishing a layered bacterial ‘immunity guard’ network.

Efficient and accurate neural-field reconstruction using resistive memory

Nature, Published online: 10 June 2026; doi:10.1038/s41586-026-10646-w

A co-optimized AI hardware–software system using resistive-memory computing improves energy efficiency and parallelism for sparse signal reconstruction in imaging and three-dimensional vision applications.

Teosinte alleles enhance nitrogen assimilation and seed protein in maize

Nature, Published online: 03 June 2026; doi:10.1038/s41586-026-10575-8

Teosinte alleles enhance nitrogen assimilation and seed protein without lowering crop yield when expressed in modern maize, providing a powerful strategy for crop improvement to meet future population demands.

Plastoglobules compartmentalize nitrogen assimilation in maize

Nature, Published online: 03 June 2026; doi:10.1038/s41586-026-10610-8

Chloroplast plastoglobules act as nitrogen-assimilation hubs in maize, with key enzymes enhancing nitrogen-use efficiency and offering new strategies for developing high-yield, sustainable crops.
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