For more than a century, pharmaceutical companies have relied on flat structures called aromatic rings, which can help drugs bind to target sites in the body. They include benzene rings and other flat, nitrogen-containing rings. But there are limits to their usefulness.

For decades, scientists have understood proteins primarily through two defining features: their amino acid sequence and their three-dimensional structure. This framework has driven major advances in biology, biotechnology and medicine, culminating in recent artificial intelligence tools capable of predicting protein structures with remarkable accuracy.

Switching to a more sustainable diet could halve food-related emissions in cities such as Amsterdam, while in cities such as Dhaka and Delhi, the focus should be more on making food production more sustainable as they widen food access. A new database by Leiden researchers shows that different cities need different approaches to achieve a more sustainable food system.

The Hammerschmiede clay pit near Pforzen in the eastern Allgäu is famous for its wealth of finds: Besides fossils of two early anthropoid apes, the remains of numerous vertebrate species have been uncovered in 11.6-million-year-old river sediments—but until now, very few birds.

To monitor the amount and type of nuclear material at power plants and weapons facilities, scientists look for a special signal—the unique pattern of gamma rays emitted by specific radioactive elements. However, some of these elements also emit X-rays in the same energy range as the gamma-ray emissions, masking the signal and making nuclear stockpiles harder to assess.

Life in the deep sea is under immense pressure—literally. Such extreme conditions can disrupt the delicate structures of proteins essential to life. Yet somehow, the proteins in deep-sea creatures remain functional. This raises an intriguing question: how?

Historical records of the deadliest storms and heat waves may be a poor indicator of the scale and impact future weather disasters could have, scientists at King's College London warn.

Even highly antibiotic-resistant bacteria become more vulnerable when their cell wall transport system is disrupted, according to a new study from Umeå University. The discovery reveals a previously overlooked weakness that could help researchers develop new strategies to combat antibiotic resistance.

Paul K. Piff, UC Irvine associate professor of psychology, has officially been recognized for what millions of frustrated commuters have long suspected: The fancier the car, the worse the driver.

Imagine this. You pick up a contact lens from its container and—yikes!—it falls on the bathroom floor. Before you know it, your cat pounces, claws out. By the time you wrestle it back, the lens looks like a tiny chew toy. And then, just like that—the scratches fade away and the ripped edge seals itself up.

Dozens of glacial lakes have formed across northern India in the last three decades, while existing lakes have expanded rapidly, highlighting the need to monitor a landscape reshaped by climate change.

Editing a plant's genes is only half the battle. Before a new, improved trait can ever reach a farmer's field, scientists must be able to grow a whole plant from just a few edited cells—a process that can be slow, unreliable and, for some plant species, impossible.

The nutritional value of aquatic invertebrates such as oysters, mussels and crabs has been significantly overlooked, according to a new study led by researchers at King Abdullah University of Science and Technology (KAUST). The findings provide one of the most comprehensive assessments to date of the nutritional contribution of aquatic invertebrates, along with new evidence to better understand their role in human nutrition and help inform more sustainable fisheries, aquaculture and food-system planning.

Scientists led by the Universitat Politècnica de Barcelona and the ESRF, the European Synchrotron, have revealed the chemical reactions in nanoparticles that created a unique, shimmering effect in the painting on ninth-century Islamic ceramics. The results are published in Science Advances.

Allowing females to mate with multiple males, rather than just one, could help make species more resistant to extinction, University of East Anglia research shows. A new study reveals that when females have multiple males to mate with, their offspring inherit significantly fewer harmful genetic mutations. This, in turn, makes the entire population healthier and less likely to die out.

The historic droughts of 2023 and 2024 in the Amazon reduced river flows and altered the region's rainfall composition. Daily monitoring in Manaus, the capital of the Brazilian state of Amazonas, revealed these changes through the use of isotopes, which act as a kind of water "fingerprint." This method demonstrated how El Niño and warming in the North Atlantic affected the origin of moisture and precipitation dynamics.

Research underway in the lab of Rebecca Alexander, a professor in Wake Forest University's Department of Chemistry, is shedding light on an unusual human bacterium, Mycoplasma penetrans. Alexander's work to understand how and why this unique pathogen acts as it does could one day lead to new classes of drugs that better target illnesses associated with this particular pathogen, as well as others that act similarly.

Unlike an animal cell, a plant cell can't crawl or migrate. It's locked inside a rigid wall, cemented to its neighbors for life. A cell born at the center of a young fruit will still be there when that fruit ripens.

Parents often learn the hard way that to make it anywhere on time, they should calculate how much time they think they need to get ready—and double it.

Within tiny halos of light clinging to a vanishingly thin wisp of optical fiber, scientist Jongmin Lee guides atoms like marbles through a narrow pipe. Rock the fiber and the atoms shift side by side; they just don't fall off. But don't be deceived by the seemingly delicate nature of his experiment. Lee is exploring how to measure motion precisely in rough-and-tumble environments.