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Received — 10 June 2026 ⏭ SCI-TECH

Molecular glue degraders of HuR suppress BRAF-mutant colorectal cancer

✇Nature
By: Xiaocui Lu · Xiuyun Wang · Zheng Yang · Xusheng Wang · Lin Wang · Chunhui Xu · I-Chung Lo · Chenlu Geng · Yisheng Pu · Keyu Zhang · Ziqiang Zhu · Lanxin Ye · Jiayuan Huang · Xiaofan Wei · Fang Bai · Yanan Zhu · Xiaobing Qian · Hao Dou · Hexiu Su · Yong Cang
10 June 2026 at 01:00

Nature, Published online: 10 June 2026; doi:10.1038/s41586-026-10613-5

Molecular glue degraders of the RNA-binding protein HuR have therapeutic potential for BRAF-mutant cancers.

A first-in-class pulsatile FXR agonist for bile-acid-related liver diseases

✇Nature
By: Yi Zang · Jingjing Shi · Guanguan Zhao · Bixi Tang · Mingliang Liu · Benqiang Yao · Gaihong Wang · Hualing Pan · Shengsheng Yang · Rong Deng · Yishuang Zhao · Zhenwei Zhang · Hao-Ran Guo · Dan-Dan Sun · Hanlin Wang · Lixin Gao · Jinghua Yu · Xingxing Diao · Yong Li · Jia Li · H. Eric Xu
10 June 2026 at 01:00

Nature, Published online: 10 June 2026; doi:10.1038/s41586-026-10633-1

Linafexor is a rapidly cleared FXR agonist designed to mimic natural bile acid signalling, achieving transient receptor activation with strong efficacy and reduced toxicity in preclinical and early clinical studies.

A high-adaptability ambient energy harvester enhanced by the canyon effect for smart agriculture

✇RSC - Energy Environment
By: Weilin Liao · Xiaosen Su · Huikang Li · Zijian Huang · Bingcheng Li · Jinsong Cai · Fei Fang · Ke Zhang · Xudong Huang · Zhong Lin Wang
10 June 2026 at 00:00

Energy Environ. Sci., 2026, Advance Article
DOI: 10.1039/D6EE02135B, Paper
Weilin Liao, Xiaosen Su, Huikang Li, Zijian Huang, Bingcheng Li, Jinsong Cai, Fei Fang, Ke Zhang, Xudong Huang, Zhong Lin Wang
This work presents a non-intrusive, modular harvester that synergistically integrates wind, solar, and raindrop energy harvesting with sensing capabilities for smart agriculture, underpinned by a canyon-effect-enhanced bi‑concave flow amplifier.
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