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Received — 10 June 2026 ⏭ SCI-TECH

A first-in-class pulsatile FXR agonist for bile-acid-related liver diseases

✇Nature
By: Yi Zang · Jingjing Shi · Guanguan Zhao · Bixi Tang · Mingliang Liu · Benqiang Yao · Gaihong Wang · Hualing Pan · Shengsheng Yang · Rong Deng · Yishuang Zhao · Zhenwei Zhang · Hao-Ran Guo · Dan-Dan Sun · Hanlin Wang · Lixin Gao · Jinghua Yu · Xingxing Diao · Yong Li · Jia Li · H. Eric Xu
10 June 2026 at 01:00

Nature, Published online: 10 June 2026; doi:10.1038/s41586-026-10633-1

Linafexor is a rapidly cleared FXR agonist designed to mimic natural bile acid signalling, achieving transient receptor activation with strong efficacy and reduced toxicity in preclinical and early clinical studies.
Received — 31 May 2026 ⏭ SCI-TECH

Enabling superior high-temperature capacitive performance in polymer dielectrics by multifunctional alternating nanolaminate coating

✇RSC - Energy Environment
By: Yuqi Liu · Jiufeng Dong · Kaixin Liu · Chengyuan Wang · Yujuan Niu · Liang Sun · Shuoyan Liu · Jiangyu Li · Jiannong Wang · Hong Wang
23 April 2026 at 00:00

Energy Environ. Sci., 2026, 19,3261-3270
DOI: 10.1039/D6EE00769D, Paper
Yuqi Liu, Jiufeng Dong, Kaixin Liu, Chengyuan Wang, Yujuan Niu, Liang Sun, Shuoyan Liu, Jiangyu Li, Jiannong Wang, Hong Wang
An alternating Al2O3/ZrO2 nanolaminate coating on polymers delivers a record discharged energy density of 8.50 J cm−3 with 96.4% efficiency at 150 °C via synergistic charge-injection blocking, deep trapping, and lateral electric field redistribution.
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