California accounts for 25% of all West Nile virus cases in the US
The California Department of Public Health (CDPH) reported 80 new West Nile virus (WNV) positive human cases reported in the state last week from the following counties: Fresno (2), Glenn (1), Los Angeles (59), Orange (11), Riverside (1), San Joaquin (1), Stanislaus (3), Tulare (1), and Yolo (1).
This brings the total human cases in California to 378 from 24 counties. This number accounts for 25.7 percent of the total WNV cases in the United States (1471).
23 WNV-related fatalities have been reported to CDPH this year from 9 jurisdictions: Butte (3), Glenn (2), Kings (1), Los Angeles (6), Orange (5), Sacramento (2), Stanislaus (1), Tuolumne (1), and Yolo (2).
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Of the 378 case patients, 321 (85%) had neuroinvasive disease. The median age of case patients was 66 years and 254 (67%) of the case patients were male.
In Los Angeles County, the Department of Public Health has documented 249 West Nile virus (WNV) human infections and 12 deaths.
West Nile virus in the US: 20 years ago in NYC
The 378 cases statewide this year is higher than 59 cases reported in 2025 and the 110 case 5 year average.
West Nile virus is the most common and serious vector-borne disease in California. There have been more than 8,000 human cases and over 400 deaths reported in California since 2003. The mosquitoes that spread WNV are found throughout the state.
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