Scientists are testing a counterintuitive way to fight mesothelioma, an aggressive asbestos-linked cancer with few effective treatments. A new experimental mesothelioma drug kills cancer cells by disabling PRX3, an antioxidant defense that tumors use to survive intense oxidative stress. In an early clinical trial, it controlled disease progression in 67% of patients and produced encouraging survival results, raising hopes that the strategy could eventually be used against other cancers.

Scientists have found the first evidence that liquid may have flowed across Pluto’s surface in the recent past. Dark features on the enormous Sputnik Planitia glacier appear consistent with liquid nitrogen rising through cracks from deep beneath the ice. Computer models show that nitrogen could melt at the glacier’s base and travel upward like fluid through small conduits. The finding reveals that Pluto may be much more geologically active than its frozen appearance suggests.

Scientists found that black and green Japanese rice contain unusual, potentially beneficial fats and may be digested more slowly than ordinary white rice. The combination could make these colorful varieties promising ingredients for foods designed to support blood sugar and metabolic health.

Scientists discovered a hidden “immune organ” inside the skull that acts as a rapid first responder against brain cancer in mice. Strengthening this local immune defense improved tumor rejection and survival, raising the possibility of new treatments that target the skull directly.

Scientists have developed a solar-powered desalination system that turns seawater into fresh water while removing nearly all of the leftover salt as a solid instead of producing harmful brine. The self-cleaning technology could also recover valuable minerals such as lithium, potentially turning desalination waste into a useful resource.

Scientists have discovered that some severe genetic disorders linked to rapid aging may be driven not just by damaged DNA, but by the body’s overreaction to that damage. When broken DNA fragments leak into the wrong part of a cell, an immune sensor called cGAS can mistake them for signs of a viral infection, triggering chronic inflammation and even interfering with DNA repair itself.

A newly identified 240-million-year-old animal from Tanzania is forcing scientists to rethink the early dinosaur timeline. Dinodontosaurus isiyavamanda belongs to a group previously known only from South America, linking fossil deposits on the two continents. That connection suggests Tanzania’s supposed oldest dinosaur fossils may actually be millions of years younger than previously thought.

Eating four to six servings of whole grains a day may deliver meaningful benefits for heart health, according to a large review of 87 clinical trials. Researchers found improvements in body weight, waist size, blood pressure, cholesterol, blood sugar, triglycerides, and some markers of inflammation.

Scientists reconstructed videos from the brain activity of mice, producing 10-second clips based only on signals from neurons in the visual cortex. The breakthrough could help reveal how the brain reshapes what we see before it becomes our perception of reality.

Venus may have once had a moon, but new research suggests the planet’s incredibly slow rotation could have doomed it. Computer simulations showed that instead of gradually drifting away like Earth’s moon, a Venusian moon would likely spiral inward until it crashed into the planet, with larger moons falling even faster.

U.S. irrigation produces some greenhouse gas emissions, but new research suggests it prevents vastly more by allowing farmers to grow more food on less land. Without irrigation, replacing lost crop yields could require converting natural ecosystems into farmland, releasing an estimated 6.86 gigatons of greenhouse gases. That is equivalent to about 363 years of current annual U.S. irrigation emissions.

A new study suggests Earth formed almost entirely from material in the inner Solar System, challenging the idea that water-rich material from beyond Jupiter played a major role. If correct, Earth’s water may have been present much closer to the young Sun than scientists previously thought.

The James Webb Space Telescope has revealed surprising changes in the rings around Chariklo, a small object orbiting between Saturn and Uranus. Over just a few years, its inner ring became more opaque while its outer ring became less opaque. The results suggest that rings around small Solar System bodies may be much more dynamic than scientists previously believed. What is causing the changes remains a mystery.

Eating more ultra-processed foods was linked to greater fat buildup inside thigh muscles, according to MRI scans of 615 adults at risk for knee osteoarthritis. Surprisingly, the association remained even after researchers accounted for calorie intake, physical activity, and other factors. Fatty changes in these muscles may weaken support around the knee and potentially increase osteoarthritis risk.

A naturally occurring molecule called erucamide may help the retina fight back against diseases that cause progressive vision loss. Restoring the molecule activated protective immune responses that helped stabilize retinal tissue and slow aspects of degeneration in preclinical models.

Older adults who changed the balance of fat, carbohydrates, and animal protein in their diets showed signs of reduced biological age after just four weeks. The strongest result appeared in participants eating an omnivorous, lower-fat, higher-carbohydrate diet.

The Hunga Tonga eruption may have triggered a surprising chemical reaction that destroyed some of the methane released into the atmosphere. Scientists say the discovery could reshape estimates of methane pollution and inspire new methods for slowing near-term global warming.

Simply smelling chocolate helped men complete more leg extension repetitions without making the workout feel harder, with dark chocolate producing the strongest effect. The researchers think familiar food aromas may influence appetite and motivation by making the brain anticipate eating.

Microscopic plant remains are revealing how GunaiKurnai ancestors used Cloggs Cave for ritual practices over thousands of years. People deliberately gathered whole grasses, carried them into the dark cave, and burned them in thin layers, leaving behind traces that may span 25,000 years. A standing stone erected around 2,000 years ago and other ritual objects strengthen the evidence that the cave was a long-lived spiritual site.

Scientists have uncovered sweeping changes in how the human brain controls and organizes its genome beginning in midlife, offering new clues to why aging sharply increases the risk of Alzheimer’s and other neurodegenerative diseases. One of the biggest shifts occurred between about ages 50 and 75, when many of the brain’s original immune cells declined and were replaced by cells with more inflammatory characteristics. Researchers also found weakening of cells that help maintain the blood-brain barrier, along with widespread deterioration in the genome’s three-dimensional organization.